He was diagnosed with a neuroedocrine tumour on March 2018. However, he recovered from it and shoot a film afterward titled Angrezi Medium. That film was supposed to be release in March of 2020 but due to coronavirus it was delayed. Now that very film would be Irrfan khan's last motion picture.
He is survived by his wife and two sons.
Here is some of the history of Irrfan Khan's movie career from TheGuardian.com:
Irrfan Khan went to drama school after failing as a cricketer. He struggled to make headway in the film industry, despite being cast in a small role in Mira Nair’s 1988 Salaam Bombay! – to his frustration he only managed to find regular work in low-grade TV soap operas.
“I came into this industry to tell stories and do cinema and I was stuck in television,” he told the Guardian in 2013.
Khan’s breakthrough role came from an unlikely source: the feature debut of then-unknown British director Asif Kapadia, whose low budget samurai-esque tale The Warrior was shot in India. Released in 2002, The Warrior was selected for the prestigious San Sebastian film festival and won the Bafta award for best British film. Khan subsequently broke into mainstream Indian films, often playing cops or villains – including the title role of Maqbool, an adaptation of Shakespeare’s Macbeth set in the Mumbai underworld. More orthodox Bollywood productions followed, such as Rog and the slice-of-life musical Life in a ... Metro.
Khan also maintained a parallel career in western cinema: he played the chief of police in Michael Winterbottom’s A Mighty Heart, and another police man in the sensationally successful Slumdog Millionaire, which went on to win eight Oscars. Later roles saw him become a reliable standby character actor in big-budget Hollywood films, playing a doctor in The Amazing Spider-Man in 2012 and businessmen in Jurassic World (2015) and Inferno (2016). In 2012 he also played the adult version of the lead character in another Oscar-winner: the Ang Lee-directed Life of Pi.
Source material: theguardian.com